EPIVIR tablets contain 300 mg of lamivudine. EPIVIR may be taken with or without food. Combivir. For the full list of excipients, see section 6.1. Found inside – Page 45for HIV (Human Immunodeficiency Virus) Infection Generic name: lamivudine/zidovudine tablets Please read this information ... COMBIVIR is the brand name of a tablet that combines EPIVIR® Tablets (lamivudine tablets) [3TC®] and RETROVIR® ... Found inside – Page 884L Lamivudine (3TC) 884.e1 L Lamivudine (3TC) (Generic Name), Epivir (Brand. 884 Lamivudine (3TC) potency loss. Evacuation occurs in 24-48 h of the initial drug dose. To promote defecation, increase fluid intake, exercise, ... Female sex and obesity may be risk factors for the development of lactic acidosis and severe hepatomegaly with steatosis in patients treated with antiretroviral nucleoside analogues. In Reverse Transcriptase Inhibitors in HIV/AIDS Therapy, leading experts in AIDS/HIV drug discovery and development review all aspects of RTIs (nucleosides, nucleotides, and non-nucleosides), including drug discovery, pharmacology, ... Drug class (es): nucleoside reverse transcriptase inhibitors (NRTIs) Lamivudine systemic is used in the treatment of: Hepatitis B. HIV Infection. Drug Name: Lamivudine [USAN:USP:INN:BAN] View Synonyms View Structure: Description: A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. EPIVIR tablets and oral solution (used to treat HIV-1 infection) contain a higher dose of the active ingredient (lamivudine) than EPIVIR-HBV tablets and oral solution (used to treat chronic HBV infection). There is no information on the effects of lamivudine on the breastfed infant or the effects of the drugs on milk production. Provided in collaboration with NIH’s Office of AIDS Research. Build-up of an acid in your blood (lactic acidosis). HIV-1 is the virus that causes Acquired Immune Deficiency Syndrome (AIDS). Below brand-name products are in CAPS, and generic products are shown in lowercase italics. Combivir generic name. All 3 trials were 2-period, crossover, open-label pharmacokinetic trials of twice- versus once-daily dosing of abacavir and lamivudine. Lamivudine has also been referred to as (-)2',3'-dideoxy, 3'-thiacytidine. Found inside – Page 79for HIV (Human Immunodeficiency Virus) Infection Generic name: lamivudine/zidovudine tablets Please read this information ... COMBIVIR is the brand name of a tablet that combines EPIVIR® Tablets (lamivudine tablets) [3TC®] and RETROVIR® ... These are not all the possible side effects of EPIVIR. Lamivudine is phosphorylated intracellularly to lamivudine triphosphate. A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. Keep staff and athletic combivir generic name trainers and match your interests, abilities, and fitness classrooms to let students know about visit the site what to do if an infected person once was. Patients with Renal Impairment: The pharmacokinetic properties of lamivudine have been determined in a small group of HIV‑1-infected adults with impaired renal function (Table 7). Lamivudine‑resistant variants of HIV‑1 have been selected in cell culture. It is taken by mouth twice a day. Description and Brand Names. Found inside – Page 42for HIV (Human Immunodeficiency Virus) Infection Generic name: lamivudine/zidovudine tablets Please read this information ... COMBIVIR is the brand name of a tablet that combines EPIVIR Tablets (lamivudine tablets) [3TC ] and RETROVIR6 ... Abacavir, dolutegravir, and lamivudine (Triumeq) is a combination medicine used to treat human immunodeficiency virus (), the virus that can cause acquired immunodeficiency syndrome (). In intent‑to‑treat analyses of 48‑week data, the proportions of subjects with HIV‑1 RNA below 400 copies per mL were 61% (33 of 54) in the group randomized to once‑daily lamivudine and 75% (39 of 52) in the group randomized to receive all 3 drugs twice daily; the proportions with HIV‑1 RNA below 50 copies per mL were 54% (29 of 54) in the once‑daily lamivudine group and 67% (35 of 52) in the all‑twice‑daily group; and the median increases in CD4+ cell counts were 166 cells per mm3 in the once‑daily lamivudine group and 216 cells per mm3 in the all‑twice‑daily group. What brand names are available for lamivudine and zidovudine? Paresthesias and Peripheral Neuropathies: Pediatric Subjects Once-Daily versus Twice-Daily Dosing (COL105677): Effect of Lamivudine on the Pharmacokinetics of Other Agents: Effect of Other Agents on the Pharmacokinetics of Lamivudine: Dose Regimen Comparison Surrogate Endpoint Trials in Therapy-Naive Adults: Figure 1. The lowest GoodRx price for the most common version of abacavir / lamivudine is around $66.45, 94% off the average retail price of $1,159.91. Combivir was approved by the U.S. Food and Drug Administration for use by people living with HIV in 1997. Each 300-mg film-coated tablet contains 300 mg of lamivudine and the inactive ingredients black iron oxide, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, and titanium dioxide. Call your healthcare provider right away if your child develops signs and symptoms of pancreatitis including severe upper stomach-area pain, with or without nausea and vomiting. This is because dolutegravir is still under patent in most high-income countries. No data are available regarding interactions with other drugs that have renal clearance mechanisms similar to that of lamivudine. Lamivudine (Epivir; Epivir HBV) is a drug prescribed for the treatment of HIV infection and hepatitis B infection. ARROW (COL105677) was a 5-year randomized, multicenter trial which evaluated multiple aspects of clinical management of HIV-1 infection in pediatric subjects. Lamivudine, a nucleoside analog, is a potent reverse transcriptase inhibitor, with IC50 value of 0.316 µM against human immunodeficiency virus type 1 (HIV-1) [1]. It is used to treat HIV disease. Modeling of pharmacokinetic data suggests increasing the dosage of EPIVIR oral solution to 5 mg per kg taken orally twice daily or 10 mg per kg taken orally once daily (up to a maximum of 300 mg daily) is needed to achieve sufficient concentrations of lamivudine [see Dosage and Administration (2.2)]. Found inside – Page 208What is the brand name for abacavir + lamivudine + zidovudine? 26. What is the generic name for Epzicom (United States) and Kivexa (Canada)? 27. What is the brand name for delavirdine? 28. What is the generic name for lamivudine + ... Action Type. Complete online or by phone. It has a molecular formula of C8H11N3O3S and a molecular weight of 229.3 g per mol.
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