No two patients are alike. The pustules, by contrast, lack surrounding erythema and leave pigmented macules with a fine white collarette of scale that can remain for many weeks. The extent of mucoutaneous, nail, dental and systemic involvement (such as oesophageal stenosis, eye, bowel, cardiac and renal disease) depends on the subtype, the junctional and dermolytic forms being more severe and sometimes lethal. Other skin changes include linear and whorled pigmentation, warty plaques and linear atrophic areas that may follow developmental (Blaschkoid) lines. 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Linearly arranged vesiculopustules, particularly on the limbs and trunk, may be incontinentia pigmenti (Figure 6). Are There Differences in Reported Symptoms and Outcomes Between Pediatric Patients with and Without Obsessive Compulsive Disorder After a Concussion? Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction. Kernicterus and neurologic sequelae caused by severe neonatal hyperbilirubinemia are preventable conditions. Conversely, cholestasis may be present in the absence of jaundice, particularly during the early stages of cholestasis. 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It responds to topical steroids and usually settles by 2 years of age. 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Clinical clues helping to differentiate serious and benign conditions are outlined, together with an approach to the initial management of common disease presentations. The book reviews the pathophysiology and genetics of the disorder, discusses recent molecular advances and its impact on diagnostics, and describes management challenges and strategies. The text also touches upon future treatment options. 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